Cortical and thalamic inputs drive distinct hippocampal microcircuits to modulate synchronized activity during development.

Synchronized activity, a hallmark of hippocampal network dynamics, appears early during development. Whether extrinsic inputs drive such activity remains unknown. In this issue of Neuron, Leprince et al.1 show that synchronized activity, while modulated by both cortical and thalamic inputs ex vivo, depends solely on cortical inputs in vivo.