Chemical constituents from Trillium camschatcense

Two undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4-7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 +/- 2.59 mu M, 56.20 +/- 1.57 mu M and 45.70 +/- 0.63 mu M.