CAPN1 (Calpain1)-Dependent Cleavage of STIM1 (Stromal Interaction Molecule 1) Results in an Enhanced SOCE (Store-Operated Calcium Entry) in Human Neonatal Platelets.

Alejandro Berna-Erro,Girish Ramesh,Elena Delgado, Antonio J Corbacho,Francisca Ferrer-Marín,Raul Teruel,María P Granados,Juan A Rosado, Pedro C Redondo

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

CAPN1 may cleave STIM1 in neonatal platelets, hence, impairing SARAF coupling after SOCE activation. s-STIM1 may avoid slow Ca-dependent inactivation and, subsequently, results in an enhanced TG-evoked SOCE as observed in neonatal platelets.

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关键词

calpeptin,mothers,stromal interaction molecule 1,thapsigargin,women

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