Protective potential of the gallbladder in primary sclerosing cholangitis.

Nora Cazzagon,Ester Gonzalez-Sanchez,Haquima El-Mourabit,Dominique Wendum,Dominique Rainteau,Lydie Humbert,Christophe Corpechot,Olivier Chazouillères,Lionel Arrivé,Chantal Housset,Sara Lemoinne

JHEP reports : innovation in hepatology（2023）

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摘要

In patients with primary sclerosing cholangitis (PSC), gallbladder status impacts on bile acid homeostasis and disease features. We found evidence of lessened bile acid toxicity in patients with PSC and enlarged gallbladders and of increased disease severity in those who were previously cholecystectomized. In the knockout mouse model of PSC, cholecystectomy causes an aggravation of cholangitis and liver fibrosis. Overall, our results suggest that the gallbladder plays a protective role in PSC.

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关键词

ABC, ATP-binding cassette transporter,Abcb4 knockout mice,BA, bile acid,Bile acids,C4, 7α-hydroxy-4-cholesten-3-one,CFTR, cystic fibrosis transmembrane conductance regulator,CK19, cytokeratin 19,Cholecystectomy,FGF19, fibroblast growth factor 19,Gallbladder volume,HPLC-MS/MS, high-performance liquid chromatography coupled to tandem mass spectrometry,IBD, inflammatory bowel disease,MRC, magnetic resonance cholangiography,Magnetic resonance imaging,PSC, primary sclerosing cholangitis,UDCA, ursodeoxycholic acid,ULN, upper limit of normal

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