The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy.

Katrine Ingelshed,Diana Spiegelberg,Pavitra Kannan, Linnéa Påvénius, Jessica Hacheney,Long Jiang,Silke Eisinger,Danai Lianoudaki,Dilraj Lama,Francisca Castillo,Cecilia Bosdotter,Warren W Kretzschmar, Omayma Al-Radi,Nicolas Fritz,Eduardo J Villablanca,Mikael C I Karlsson,Fredrik Wermeling,Marika Nestor,David P Lane,Saikiran K Sedimbi

Cancer research communications（2022）

引用 2|浏览21

暂无评分

摘要

The MDM2 inhibitor Navtemadlin arrests mouse tumor growth and potentiates radiotherapy. Our results support a threshold model for apoptosis induction that requires a high, prolonged p53 signaling for cancer cells to become apoptotic.

查看译文

关键词

melanoma,potentiates radiotherapy,inhibitor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要