Progressive alterations in white matter microstructure across the timecourse of Huntington's disease.

Carlos Estevez-Fraga,Michael S Elmalem,Marina Papoutsi,Alexandra Durr,Elin M Rees,Nicola Z Hobbs,Raymund A C Roos,Bernhard Landwehrmeyer,Blair R Leavitt,Douglas R Langbehn,Rachael I Scahill,Geraint Rees,Sarah J Tabrizi,Sarah Gregory

Brain and behavior（2023）

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摘要

The present study showed significant longitudinal changes in WM microstructure across the HD timecourse. Changes were evident in larger WM areas and across more metrics as the disease advanced, suggesting a progressive alteration of WM microstructure with disease evolution.

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关键词

Huntington's disease,diffusion tensor imaging,longitudinal,presymptomatic,symptomatic

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