Loss of function SMAD4 nonstop mutations in human cancer.

Anna H Bauer,David W Basta,Jason L Hornick,Fei Dong

Histopathology（2023）

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摘要

SMAD4 nonstop mutations are associated with loss of SMAD4 protein expression in multiple tumour types. SMAD4 nonstop mutations should be clinically interpreted as pathogenic loss of function alterations when identified in cancer sequencing panels.

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关键词

SMAD4,cancer sequencing,immunohistochemistry,molecular pathology,nonstop

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