Association of Complement and Coagulation Pathway Proteins With Treatment Response in First-Episode Psychosis: A Longitudinal Analysis of the OPTiMiSE Clinical Trial.

Subash Raj Susai,Melanie Föcking,David Mongan,Meike Heurich,Fiona Coutts,Alice Egerton, Tony Whetton,Inge Winter-van Rossum, Richard D Unwin,Thomas A Pollak,Mark Weiser,Marion Leboyer,Dan Rujescu,Jonah F Byrne,George W Gifford,Paola Dazzan,Nikolaos Koutsouleris,René S Kahn,David R Cotter,Philip McGuire

Schizophrenia bulletin（2023）

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摘要

The results demonstrated that the response to antipsychotic treatment might be related to pre-treatment levels of plasma complement and coagulation pathway proteins. This is consistent with independent evidence associating immune dysfunction with the pathophysiology of psychosis. Moreover, these results inform the development of novel therapeutic approaches that target the complement system for psychosis.

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关键词

Schizophrenia,antipsychotic agents,biomarkers,complement system proteins,immune markers,psychotic disorder

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