Molecular genetic characteristics of thymic epithelial tumors with distinct histological subtypes.

Jun Yang,Biao Zhang,Wenyan Guan,Zhiwen Fan,Xiaohong Pu,Linyue Zhao,Wen Jiang,Weijing Cai,Xueping Quan,Shuying Miao,Ling Nie,Lu He

Cancer medicine（2023）

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摘要

This study revealed distinct molecular landscapes of different subtypes of TETs, suggesting diverse pathogenesis of non-B3 thymomas, B3 thymomas, and TCs. Our findings warrant further validation in future large-scale studies and may provide a theoretical basis for potential personalized therapeutic strategies.

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关键词

amplified segments,copy number variation burden,thymic carcinomas,thymic epithelial tumors,thymomas,weighted genome instability index

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