Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.

Ning Chang,Jianhua Feng,Peiyun Liao,Yuxing Hu,Meifang Li,Yanjie He,Yuhua Li

Translational cancer research（2023）

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摘要

Our research demonstrated that MEF2D was markedly expressed in B-ALL. MEF2D knockdown inhibited cancer progression of B-ALL both and , which may be related to the downregulation of the PI3K-AKT signaling pathway. The data suggest that MEF2D plays a vital role in the process of tumorigenesis and may be a potential novel target for B-ALL therapy.

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关键词

B-cell acute lymphoblastic leukemia (B-ALL),myocyte enhancer factor 2D (MEF2D),phosphatidylinositol-4,5-bisphosphate 3-kinase-protein kinase B (PI3K-AKT),tumor progression

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