Honokiol, an inducer of Sirtuin 3, protects against NSAID-induced gastric mucosal mitochondrial pathology, apoptosis and inflammatory tissue injury.

Subhashis Debsharma,Saikat Pramanik,Samik Bindu,Somnath Mazumder,Troyee Das,Debanjan Saha,Rudranil De,Shiladitya Nag,Chinmoy Banerjee,Asim Azhar Siddiqui,Zhumur Ghosh,Uday Bandyopadhyay

British journal of pharmacology（2023）

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摘要

Sirtuin-3 stimulation by HKL prevented as well as restored NSAID-induced gastric injury through maintaining mitochondrial integrity. HKL did not affect gastric acid secretion. Sirtuin-3 stimulation by HKL may be capitalized as a mitochondria-based, acid-independent novel gastroprotective strategy against NSAIDs.

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关键词

Apoptosis,Gastric injury,Honokiol,Mitochondria,Non-steroidal anti-inflammatory drugs,Sirtuin-3

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