Feasibility of the novel vascular disrupting agent C118P for facilitating high-intensity focused ultrasound ablation of uterine fibroids.

Yue Li,Jinyong Zhang,Changlian Lu, Mingrui Guo, Jue Zhang,Gang Huang,Yicheng Ni,Yini Chen

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group（2023）

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摘要

This study confirmed that C118P could reduce blood perfusion in various tissues and had a better synergistic effect with HIFU ablation of muscle (the same tissue type as fibroids) than did oxytocin. C118P could therefore possibly replace oxytocin in facilitating HIFU ablation of uterine fibroids; however, electrocardiographic monitoring is required.

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关键词

Vascular disrupting agent,blood perfusion,high-intensity focused ultrasound,laser speckle flow imaging,vasoconstriction

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