Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism

HomeCirculationVol. 147, No. 11Perm1 Protects the Heart From Pressure Overload–Induced Dysfunction by Promoting Oxidative Metabolism No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextPerm1 Protects the Heart From Pressure Overload–Induced Dysfunction by Promoting Oxidative Metabolism Shizuko Tachibana, Nam-Kyung Yu, Ruixia Li, Carolina Fernandez-Costa, Alex Liang, Janet Choi, Dayoen Jung, Changchun Xiao, Anastasia Kralli, John R. Yates III, Robert S. Ross and Yoshitake Cho Shizuko TachibanaShizuko Tachibana Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Search for more papers by this author , Nam-Kyung YuNam-Kyung Yu Departments of Molecular Medicine and Neurobiology (N.-K.Y., C.F.-C., J.R.Y.), The Scripps Research Institute, La Jolla, CA. Search for more papers by this author , Ruixia LiRuixia Li Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA (R.L., A.L., R.S.R., Y.C.). Search for more papers by this author , Carolina Fernandez-CostaCarolina Fernandez-Costa Departments of Molecular Medicine and Neurobiology (N.-K.Y., C.F.-C., J.R.Y.), The Scripps Research Institute, La Jolla, CA. Search for more papers by this author , Alex LiangAlex Liang Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA (R.L., A.L., R.S.R., Y.C.). Search for more papers by this author , Janet ChoiJanet Choi Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Search for more papers by this author , Dayoen JungDayoen Jung Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Search for more papers by this author , Changchun XiaoChangchun Xiao Department of Immunology and Microbiology (C.X.), The Scripps Research Institute, La Jolla, CA. Search for more papers by this author , Anastasia KralliAnastasia Kralli Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (A.K.). Search for more papers by this author , John R. Yates IIIJohn R. Yates III Departments of Molecular Medicine and Neurobiology (N.-K.Y., C.F.-C., J.R.Y.), The Scripps Research Institute, La Jolla, CA. Search for more papers by this author , Robert S. RossRobert S. Ross Correspondence to: Robert S. Ross, MD, MBA, Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email E-mail Address: [email protected] https://orcid.org/0000-0003-2195-8982 Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA (R.L., A.L., R.S.R., Y.C.). Search for more papers by this author and Yoshitake ChoYoshitake Cho Correspondence to: Yoshitake Cho, PhD, Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email E-mail Address: [email protected] https://orcid.org/0000-0002-7161-3248 Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.). Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA (R.L., A.L., R.S.R., Y.C.). Search for more papers by this author Originally published13 Mar 2023https://doi.org/10.1161/CIRCULATIONAHA.122.060173Circulation. 2023;147:916–919FootnotesCirculation is available at www.ahajournals.org/journal/circFor Sources of Funding and Disclosures, see page 919.Correspondence to: Yoshitake Cho, PhD, Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email [email protected]ucsd.eduCorrespondence to: Robert S. Ross, MD, MBA, Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093. Email [email protected]ucsd.eduReferences1. Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, et al. Expert consensus document: mitochondrial function as a therapeutic target in heart failure.Nat Rev Cardiol. 2017; 14:238–250. doi: 10.1038/nrcardio.2016.203CrossrefMedlineGoogle Scholar2. Cho Y, Tachibana S, Lam K, Arita Y, Khosrowjerdi S, Zhang O, Liang A, Li R, Andreyev A, Kralli A, et al. Correction: Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.J Biol Chem. 2021; 297:101121. doi: 10.1016/j.jbc.2021.101121CrossrefMedlineGoogle Scholar3. Rauniyar N, Yates JR. Isobaric labeling-based relative quantification in shotgun proteomics.J Proteome Res. 2014; 13:5293–5309. doi: 10.1021/pr500880bCrossrefMedlineGoogle Scholar4. Rampelt H, Zerbes RM, van der Laan M, Pfanner N. Role of the mitochondrial contact site and cristae organizing system in membrane architecture and dynamics.Biochim Biophys Acta Mol Cell Res. 2017; 1864:737–746. doi: 10.1016/j.bbamcr.2016.05.020CrossrefMedlineGoogle Scholar5. Bock T, Turk C, Aravamudhan S, Keufgens L, Bloch W, Rozsivalova DH, Romanello V, Nogara L, Blaauw B, Trifunovic A, et al. PERM1 interacts with the MICOS-MIB complex to connect the mitochondria and sarcolemma via ankyrin B.Nat Commun. 2021; 12:4900. doi: 10.1038/s41467-021-25185-3CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails March 14, 2023Vol 147, Issue 11 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.122.060173PMID: 36913499 Originally publishedMarch 13, 2023 KeywordsMICOSoxidative metabolismmitochondriapressure overloadPerm1PDF download Advertisement SubjectsHypertrophyRemodeling