Chemical control of phase separation in DNA solutions.

Chemical communications (Cambridge, England)（2023）

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摘要

We designed a series of DNA sequences comprising a trinucleotide repeat segment and a small molecule-binding aptamer. Optimization of the DNA sequences and reaction conditions enabled chemical control of phase separation of DNA condensates. Our results demonstrate a new strategy to regulate biomolecular phase transition.

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关键词

phase separation,dna,chemical control

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