The role of indoleamine 2,3-dioxygenase 1 in early-onset post-stroke depression.

Hengshu Chen,Xia Huang,Chang Zeng,Dongren Sun,Fan Liu,Jingyuan Zhang,Qiao Liao,Shihang Luo,Weiye Xu,Yeqing Xiao,Danfeng Zeng,Mingyu Song,Fafa Tian

Frontiers in immunology（2023）

引用 6|浏览9

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摘要

Our findings provided evidence that IDO1 gene polymorphisms and protein levels were involved in the development of early-onset PSD and TNF-α polymorphism was associated with IDO1 levels, supporting that IDO1 which underlie strongly regulation by cytokines may be a specific pathway for the involvement of immune-inflammatory mechanism in the pathophysiology of PSD.

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关键词

immune-inflammatory response,indoleamine 2,3-dioxygenase,post-stroke depression,pro-inflammatory cytokine,single nucleotide polymorphism

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