Tumor-derived GCSF Alters Tumor and Systemic Immune System Cell Subset Composition and Signaling.

Israel Matos, Maunish Barvalia,Manreet K Chehal,A Gordon Robertson, Iva Kulic, Jessica A F D Silva, Abhinandan Ranganathan, Amy Short,Yu-Hsuan Huang,Erin Long,John J Priatel,Salim Dhanji,Brad H Nelson,Danielle L Krebs,Kenneth W Harder

Cancer research communications（2023）

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摘要

Tumor-derived GCSF leads to systemic immune population changes. GCSF blockade restores immune populations, improves immunotherapy, and reduces tumor size, paralleling human colorectal cancer data. GCSF inhibition may synergize with current immunotherapies to treat GCSF-secreting tumors.

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gcsf alters tumor-derived

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