PASSED: Brain atrophy in non-demented individuals in a long-term longitudinal study from two independent cohorts.

Anna-Lena Haas,Pauline Olm,Janine Utz,Eva-Maria Siegmann,Philipp Spitzer, Anna Florvaag,Manuel Alexander Schmidt,Arnd Doerfler,Piotr Lewczuk,Johannes Kornhuber,Juan Manuel Maler,Timo Jan Oberstein

Frontiers in aging neuroscience（2023）

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摘要

In this study, nondemented subjects with PASSED did not show a unique longitudinal atrophy pattern in comparison to nondemented subjects with AD. The nonsignificant atrophy rate compared with controls suggests that increased pTau181-levels without concomitant amyloidopathy did not indicate a neurodegenerative disorder.

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关键词

ATN classification,Alzheimer disease/physiopathology*,SNAP,amyloid beta-peptides/cerebrospinal fluid*,longitudinal studies,magnetic resonance imaging,medial temporal lobe,tau proteins/cerebrospinal fluid*

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