Efficacy and safety of PARP inhibitors in the treatment of BRCA-mutated breast cancer: an updated systematic review and meta-analysis of randomized controlled trials.

Xiaoyu Sun,Suying Xu,Yiming Li,Xuemei Lv,Minjie Wei,Miao He

Expert review of clinical pharmacology（2023）

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摘要

Our results confirm the efficacy and safety of PARPis in patients with BRCA-mutated breast cancer, and more specifically clarify the efficacy of PARPis alone or in combination with other chemotherapy drugs. [Figure: see text].

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关键词

BRCA mutations,PARP inhibitors,breast cancer,efficacy,meta-analysis,safety

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