Shengjiang Xiexin Decoction ameliorates antibiotic-associated diarrhea by altering the gut microbiota and intestinal metabolic homeostasis

Cong-En Zhang,Xiao-Hong Yu,Yu-Tao Cui,Huan-Jun Wang,Xi Chen,Xiao-Jing Ma,Hui Li,Jian-Rong Su,Zhi-Jie Ma,Lu-Qi Huang

Phytomedicine（2023）

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摘要

•Shengjiang Xiexin Decoction (SXD) effectively ameliorated AAD.•SXD recovered disordered gut microbiota in AAD rats.•SXD partly improved the integrity of intestinal barrier in AAD rats.•SXD recovered perturbed metabolic homeostasis in AAD rats.•Clear correlation among gut microbiota and metabolic profile was found.

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关键词

Antibiotic-associated diarrhea,Shengjiang Xiexin Decoction (SXD),Gut microbiota,Intestinal metabolic homeostasis,Intestinal barrier function

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