Antimicrobial Activity of Sertraline on Listeria monocytogenes .

We explored the antimicrobial activity of sertraline on and further investigated the effects of sertraline on biofilm formation and the virulence gene expression of . The minimum inhibitory concentration and minimum bactericidal concentration for sertraline against were in the range of 16-32 μg/mL and 64 μg/mL, respectively. Sertraline-dependent damage of the cell membrane and a decrease in intracellular ATP and pH in were observed. In addition, sertraline reduced the biofilm formation efficiency of the strains. Importantly, low concentrations (0.1 μg/mL and 1 μg/mL) of sertraline significantly down-regulated the expression levels of various virulence genes (, , , , , and ). These results collectively suggest a role of sertraline for the control of in the food industry.