From Dinitrogen to N-Containing Organic Compounds: Using Li 2 CN 2 as a Synthon.

Through the synergies of a heterogeneous synthetic approach and a homogeneous synthetic methodology, N-containing organic compounds can be synthesized via activated N-containing species prepared from N gas and suitable carbon sources. From N , carbon, and LiH, we have previously succeeded in the high-yield preparation of Li CN as the activated N-containing species. In this work, we applied Li CN as a novel synthetic synthon for constructing N-containing organic compounds. A series of reaction models, including a substitution reaction, cycloaddition reaction, and transition metal-catalyzed coupling reaction, were successfully performed using Li CN under mild conditions. Various valuable cyanamides, carbodiimides, N-aryl cyanamides and 1,2,4-triazole derivatives were readily synthesized in moderate to excellent yields. With this method, the N-labeled products, including oxazolidine derivatives with anti-cancer activity, could also be facilely prepared from N gas.