CRISPR-based screening identifies XPO7 as a positive regulator of senescence

Lan-Zhu Li,Kuan Yang,Yaobin Jing,Yanling Fan,Xiaoyu Jiang,Si Wang,Guang-Hui Liu,Jing Qu,Shuai Ma,Weiqi Zhang

Protein & cell（2023）

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摘要

Dear Editor, Cells enter senescence,or irreversible growth arrest,when exposed to stressors such as DNA damage,epigenetic altera-tions and chronic inflammation(Zhao and Chen,2022).In aging and aging-related diseases,senescent cells are known to accu-mulate across tissues and organs(Sun et al.,2022;Lopez-Otin et al.,2023).

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senescence,screening identifies,crispr-based

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