HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice.

Hepatology (Baltimore, Md.)（2023）

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摘要

PC and BCP mutations were associated with enhanced viral replication and cell death induced by ER stress using HBV infection models. These mutations might be associated with liver damage in patients with fulminant hepatitis or HBV reactivation.

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关键词

basal precore promoter mutations,high replication phenotype,cell death,stress-mediated

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