Indoxyl sulfate induces left ventricular hypertrophy via the AhR-FGF23-FGFR4 signaling pathway.

Hiroshi Kishimoto,Toshiaki Nakano,Kumiko Torisu,Masanori Tokumoto,Yushi Uchida,Shunsuke Yamada,Masatomo Taniguchi,Takanari Kitazono

Frontiers in cardiovascular medicine（2023）

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摘要

This study suggests that IS increases FGF23 protein expression via an increase in GALNT3 and hypoxia-inducible factor 1 alpha expression, and activates FGF23-FGFR4 signaling in cardiomyocytes, leading to LVH.

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关键词

aryl hydrocarbon receptor,fibroblast growth factor 23,fibroblast growth factor receptor 4,indoxyl sulfate,left ventricular hypertrophy

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