Mitochondrial dysfunction caused by SIRT3 inhibition drives proinflammatory macrophage polarization in obesity.

Qing Zhou,Yuyan Wang,Zongshi Lu,Bowen Wang,Li Li,Mei You,Lijuan Wang,Tingbing Cao,Yu Zhao,Qiang Li,Aidi Mou,Wentao Shu,Hongbo He,Zhigang Zhao,Daoyan Liu,Zhiming Zhu,Peng Gao,Zhencheng Yan

Obesity (Silver Spring, Md.)（2023）

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摘要

This study emphasizes an important preventive role of SIRT3 in macrophage polarization and implies that SIRT3 is a promising therapeutic target for obesity.

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