A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.

Yoshinobu Saito,Dingzi Yin,Naoto Kubota,Xiaobo Wang,Aveline Filliol,Helen Remotti,Ajay Nair,Ladan Fazlollahi,Yujin Hoshida,Ira Tabas,Kirk J Wangensteen,Robert F Schwabe

Gastroenterology（2023）

引用 4|浏览32

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摘要

Our results suggest the cholesterol-TAZ-TEAD2-ANLN/KIF23 pathway as a mediator of HCC proliferation and tumor cell-intrinsic therapeutic target that could be synergistically combined with TIME-targeted therapies.

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关键词

Anillin,CRISPR,Combination Therapy,Immune Checkpoint Inhibition,Kinesin Family Member 23,Liver Cancer,Statin,Tyrosine Kinase Inhibitor,VT104,VT107

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