VX-765 inhibits pyroptosis and reduces inflammation to prevent acute liver failure by upregulating PPARα expression.

Mingjing Jiao,Jiachao Wang,Wenpeng Liu,Xin Zhao,Yanjun Qin,Chunhuan Zhang,Hongzhu Yin,Caiyan Zhao

Annals of hepatology（2023）

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摘要

As ALF progresses, inflammatory responses and pyroptosis deteriorate gradually. VX-765 can inhibit pyroptosis and reduce inflammatory responses to protect against ALF by upregulating PPARα expression, thus providing a possible therapeutic strategy for ALF.

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关键词

Acute liver failure,NF-κB,Peroxisome proliferator-activated receptor α,Pyroptosis,VX-765

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