Getaway car: Fungal HscA steers human phagosomal p11 into an escape route.

In this issue of Cell Host & Microbe, Jia and colleagues discover how the human p11 (s100A10)-Anxa2 heterodimer drives sorting of microbial phagosomes into recycling versus degradative pathways. In a remarkable evolutionary arms race, the Aspergillus fumigatus protein HscA latches to p11 to steer its phagosome away from fungal killing.