Biomimetic melatonin-loaded silk fibroin/GelMA scaffold strengthens cartilage repair through retrieval of mitochondrial functions

Mingzhuang Hou,Yijian Zhang,Yang Liu,Xiaoyang Ge,Xiayu Hu,Zhijian Zhao,Xin Tian,Tao Liu,Huilin Yang,Xi Chen,Fan He,Xuesong Zhu

Journal of Materials Science & Technology（2023）

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摘要

•SF-GelMA@MT scaffold was fabricated with aqueous-based procedures plus photocurable surface modification.•Prolonged released melatonin facilitated cartilage ECM production via mitochondrial enhancement.•Activated SIRT1-SOD2 signaling pathway was implicated in SF-GelMA@MT-induced chondroprotective effects.•In situs implantation of SF-GelMA@MT promoted cartilage regeneration in full-thickness cartilage defect model.

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关键词

Cartilage injury,Silk fibroin,Gelatin methacrylate,Melatonin,Mitochondria

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