Sustained release properties of liquid crystal functionalized poly (amino acid)s nanoparticles

•Polyamino acid were synthesized with cholesterol was grafted to show liquid crystal propery.•Amphiphilic copolymers could be self-assembly to form spherical nanoparticles to realize drug-loaded.•Nanoparticles have good biocompatibility and sensitive to dual pH and temperature.•Drug release behavior was improved by liquid crystal properties.