Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis.

Emilie Coppin,Xinyi Zhang,Lee Ohayon,Ebin Johny, Ankush Dasari,Kang H Zheng,Lotte Stiekema,Eugenia Cifuentes-Pagano,Patrick J Pagano,Srilakshmi Chaparala,Erik S Stroes,Partha Dutta

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

Our findings demonstrate increased inflammation, HSPC abundance in the vascular niches of the bone marrow, and elevated IL-3Rb and IL-1R1 (IL-1 receptor 1) expression in HSPC following HI. Furthermore, the IL-3Rb and IL-1R1 signaling plays a pivotal role in HSPC proliferation, leukocyte abundance, and atherosclerosis aggravation after HI.

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关键词

atherosclerosis,hematopoiesis,inflammation,myelopoiesis,peripheral artery disease

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