Spontaneous Osteoclastogenesis, a risk factor for bone metastasis in advanced luminal A-type breast cancer patients.

Valeria Fernández Vallone,Francisco Raúl Borzone,Leandro Marcelo Martinez,María Belén Giorello,Hosoon Choi,Federico Dimase,Leonardo Feldman,Raúl Horacio Bordenave, Ana Marisa Chudzinski-Tavassi,Emilio Batagelj,Norma Alejandra Chasseing

Frontiers in oncology（2023）

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摘要

The discovery of prognostic biomarkers and novel therapeutic targets linked to bone metastasis initiation and development are a promising perspective for preventive treatments and metastasis management in advanced breast cancer patients.

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关键词

CCL-2,RANKL,bone metastasis,pre-metastatic niche,spontaneous osteoclastogenesis

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