Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia.

Michael Ohene-Nyako,Sara R Nass,Hope T Richard, Robert Lukande,Melanie R Nicol,MaryPeace McRae,Pamela E Knapp,Kurt F Hauser

ASN neuro（2023）

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摘要

HIV/HIV-1 Tat and morphine independently increase pathologic phosphorylation of TAR DNA binding protein 43 in the striatum. HIV- and opioid-induced pathologic phosphorylation of TAR DNA binding protein 43 may involve enhanced CK2 activity and protein levels.

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关键词

CX-4945 (Silmitasertib),TDP-43 proteinopathy,casein kinase 2,inositol-triphosphate 3-kinase B,neuro-acquired human immunodeficiency syndrome (neuroHIV),opioid use disorder

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