NEPHROPROTECTIVE EFFECT OF GAMMA-SECRETASE INHIBITOR ON SEPSIS- INDUCED RENAL INJURY IN MOUSE MODEL OF CLP.

Fadha Abdulameer Ghafil,Sahar A Majeed,Heider Qassam,Haider W Mardan,Najah R Hadi

Wiadomosci lekarskie (Warsaw, Poland : 1960)（2023）

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摘要

Conclusions: Taken together, these results suggest that MK0752 could be protective against the renal injury induced by sepsis through its ameliorative impact on renal architecture and modulating cytokines and Notch1 singling pathway. Further studies regarding the role of Notch signaling pathways would be worthwhile.

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关键词

MK0752, a gamma-secretase inhibitor, endotoxemia, jagged1and cecal ligation, notch1, puncture, sepsis

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