Paeoniflorin protects 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mice by inhibiting oxidative stress and neuronal apoptosis through activating the Nrf2/HO-1 signaling pathway.

Jingyan Zhang,Qingyang Bai,Qiuting Wen,Lijun Han,Yan Shi,Xiaojie Zhang

Neuroreport（2023）

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摘要

Neuroprotective effects of paeoniflorin in MPTP-induced PD mice may be mediated via inhibition of oxidative stress and apoptosis of dopaminergic neurons in substantia nigra through activation of the Nrf2/HO-1 signaling pathway.

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关键词

apoptosis,heme oxygenase-1,Nrf2,oxidative stress,Parkinson's disease

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