AI 检索
AI 阅读
analysis
趋势分析
编组
开放平台
more
更多
排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
VIPCreated with Sketch.

Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol.

K van Kuijk,I R McCracken,R J H A Tillie,S E J Asselberghs,D A Kheder, S Muitjens,H Jin,R S Taylor,R Wichers Schreur,C Kuppe,R Dobie,P Ramachandran,M J Gijbels,L Temmerman,P M Kirkwoord,J Luyten,Y Li,H Noels,P Goossens,J R Wilson-Kanamori,L J Schurgers, Y H Shen,B M E Mees,E A L Biessen,N C Henderson,R Kramann,A H Baker,J C Sluimer

Cardiovascular research（2023）

引用 2|浏览30
暂无评分
摘要
We provide two adventitial fibroblast-specific markers, PDGFRA and DPEP1, and demonstrate fibroblast heterogeneity in health and cardiovascular disease in humans and mice. Biological relevance is evident from regulation of fibroblast clusters by age and hypercholesterolemia in vivo, associations with human atherosclerotic plaque traits, and enrichment of genes with a GWAS for CVD.
更多
查看译文
关键词
Adventitia,Atherosclerosis,Fibroblasts,Heterogeneity,Single-cell RNA-Seq
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要