SIRT1 Inhibits High Glucose-Induced TXNIP/NLRP3 Inflammasome Activation and Cataract Formation.

Lili Lian,Zhenmin Le,Zhenzhen Wang,Ying-Ao Chen,Xiaodong Jiao, Hang Qi,J Fielding Hejtmancik,Xiaoyin Ma,Qinxiang Zheng,Yueping Ren

Investigative ophthalmology & visual science（2023）

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摘要

The TXNIP/NLRP3 inflammasome pathway promotes HG-induced inflammation and HLEC pyroptosis, which is negatively regulated by SIRT1. This suggests viable strategies for treating diabetic cataract.

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关键词

diabetic cataract,NLRP3 inflammasome,SIRT1,TXNIP

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