Fibrinogen-like protein 2 promotes proinflammatory macrophage polarization and mitochondrial dysfunction in liver fibrosis

Ran Tao,Meiwen Han,Wei Yuan,Fang Xiao,Jiaquan Huang,Xiaojing Wang,Xiaoping Luo,Weiming Yan,Xiaoyang Wan,Qin Ning

International Immunopharmacology（2023）

引用 3|浏览27

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摘要

•Liver fibrosis progression is related to hepatic Fgl2 upregulation.•Fgl2 promotes the proinflammatory macrophage polarization.•Fgl2 interacts with HSP90 and localizes to mitochondria.•Fgl2 disrupts the HSP90-Akt interaction and modulates the Akt/FoxO1 pathway in macrophages.

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关键词

Fibrinogen-like protein 2,Liver fibrosis,Macrophage polarization,Mitochondrial reactive oxygen species,Mitochondrial dysfunction

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