Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation

International Immunopharmacology(2023)

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摘要
•Sepsis elevated the levels of CGRP in serum and intestinal tissue of mice.•CGRP restrained the activation of the intestinal NLRP3 inflammasome in mice.•CGRP relieved sepsis-induced intestinal barrier injury.
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关键词
Calcitonin gene-related peptide,NLRP3 inflammasome,Sepsis,Intestinal injury,Inflammation
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