Associations of polygenic risk scores with posttraumatic stress symptom trajectories following combat deployment.

Laura Campbell-Sills,Santiago Papini,Sonya B Norman,Karmel W Choi,Feng He,Xiaoying Sun,Ronald C Kessler,Robert J Ursano,Sonia Jain,Murray B Stein

Psychological medicine（2023）

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摘要

Higher polygenic risk for PTSD or MDD is associated with more severe posttraumatic stress symptom trajectories following combat deployment. PRS may help stratify at-risk individuals, enabling more precise targeting of treatment and prevention programs.

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关键词

Latent growth mixture modeling,military personnel,polygenic risk scores,posttraumatic stress,trauma

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