Discriminatory Changes in Circulating Metabolites as a Predictor of Hepatocellular Cancer in Patients with Metabolic (Dysfunction) Associated Fatty Liver Disease.

Haonan Lu,Jacob George,Mohammed Eslam,Augusto Villanueva,Luigi Bolondi,Helen L Reeves,Misti McCain,Edward Chambers,Caroline Ward, Dewi Sartika,Caroline Sands,Lynn Maslen,Matthew R Lewis,Ramya Ramaswami,Rohini Sharma

Liver cancer（2023）

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摘要

These exploratory findings reveal a metabolic signature in serum which is capable of accurately detecting the presence of HCC on a background of MAFLD. This unique serum signature will be taken forward for further investigation of diagnostic performance as biomarker of early stage HCC in patients with MAFLD in the future.

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Detection,Hepatocellular cancer,Lipidomics,Metabolic (dysfunction) associated fatty liver disease,Metabolomics,Survival

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