The protective effect of IL-12/23 neutralizing antibody in sarcopenia associated with dextran sulfate sodium-induced experimental colitis.
Journal of cachexia, sarcopenia and muscle(2023)
摘要
Our study demonstrates that Il-12/23 acts directly on muscle to induce atrophy, and the IL-12/23 p40 neutralizing antibody is effective not only in suppressing colitis but also in maintaining muscle mass and improving muscle function in an experimental colitis model.
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关键词
IL1,IL23,inflammatory bowel disease,neutralizing antibody,sarcopenia
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