Validating the total cancer location density metric for stratifying patients with low-risk localized prostate cancer at higher risk of grade group reclassification while on active surveillance

Guan Hee Tan,Dominik Deniffel,Antonio Finelli,Marian Wettstein,Ardalan Ahmad,Alexandre Zlotta,Neil Fleshner,Robert Hamilton,Girish Kulkarni,Gregory Nason,Khaled Ajib,Jaime Herrera-Caceres,Thenappan Chandrasekar,Nathan Perlis

Urologic Oncology: Seminars and Original Investigations（2023）

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摘要

•Grade group reclassification occurs in some men on active surveillance for prostate cancer.•Greater number of cancer locations (TCLo) is associated with grade group reclassification.•A large proportion of men with high TCLo density were found to have higher grade disease.•Men with low TCLo density had better progression-free survival.

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关键词

Active surveillance,Prostate Cancer,Progression of Disease,Validation

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