Perinatal Protein Restriction Impacts Nuclear O-GalNAc Glycosylation in Cells of Liver and Brain Structures of the Rat.

Yohana Camila Garay,Romina Beatriz Cejas,Maria Cecilia Perondi, Maria Cecilia Gutiérrez,Pedro Parodi,Franco Alejandro Ferrero,Ricardo Dante Lardone,Analía Valdomero,Gabriel Ricardo Cuadra,Fernando José Irazoqui

The Journal of nutrition（2023）

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摘要

Our results report an association between the consumption of a protein-restricted diet by the dam and her progeny with the modulation in the offspring' liver nuclei O-GalNAc glycosylation, which may ultimately regulate nuclear protein functions.

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关键词

O-GalNAc glycans,glycosyltransferase activity,nucleus,perinatal undernutrition,post-translational modification

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