Population pharmacokinetics of unbound and total dolutegravir concentrations in children aged 12 years and older: a PK substudy of the SMILE trial.

Seef Abdalla,Alexandra Compagnucci,Yi Zheng,Jean-Marc Tréluyer,Yacine Saidi,José T Ramos,Alexandra Coelho,Yoann Riault,Tim R Cressey,Déborah Hirt

The Journal of antimicrobial chemotherapy（2023）

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摘要

A once-daily 50 mg dolutegravir dose for children and adolescents produces adequate total and unbound concentrations when used as part of dual therapy with ritonavir-boosted darunavir.

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关键词

total dolutegravir concentrations,pharmacokinetics,children

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