Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study.
The Journal of clinical endocrinology and metabolism（2023）
摘要
MIB-626 administration in overweight or obese, middle-aged and older adults safely increased circulating NAD levels, and significantly reduced total LDL and non-HDL cholesterol, body weight, and diastolic blood pressure. These data provide the rationale for larger trials to assess the efficacy of NAD augmentation in improving cardiometabolic outcomes in older adults.
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关键词
blood pressure,geroscience,lipids,metabolic effects,muscle bioenergetics,physical function,β-nicotinamide mononucleotide
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