Functional estrogen receptor signal transduction pathway activity and antihormonal therapy response in low-grade ovarian carcinoma.

Cynthia S E Hendrikse,Phyllis van der Ploeg,Nienke M A van de Kruis,Jody H C Wilting,Floor Oosterkamp,Pauline M M Theelen,Christianne A R Lok,Joanne A de Hullu,Huberdina P M Smedts,M Caroline Vos,Brenda M Pijlman,Loes F S Kooreman,Johan Bulten,Marjolein H F M Lentjes-Beer,Steven L Bosch,Anja van de Stolpe,Sandrina Lambrechts,Ruud L M Bekkers,Jurgen M J Piek

Cancer（2023）

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摘要

Aberrant low and very high functional ER STP activity and low PR histoscores in patients with LGOC indicate decreased response to AHT. ER IHC is not representative of functional ER STP activity and is not related to PFS.

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关键词

antihormonal therapy,immunohistochemistry,ovarian carcinoma,signal transduction pathway,survival,targeted therapy

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