Elevated serum levels of glial fibrillary acidic protein are associated with covert hepatic encephalopathy in patients with cirrhosis.

Simon Johannes Gairing,Sven Danneberg,Leonard Kaps,Michael Nagel,Eva Maria Schleicher, Charlotte Quack,Sinah Engel,Stefan Bittner,Peter Robert Galle,Jörn Markus Schattenberg,Marcus-Alexander Wörns,Felix Luessi,Jens Uwe Marquardt,Christian Labenz

JHEP reports : innovation in hepatology（2023）

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摘要

Blood biomarkers facilitating the diagnosis of covert hepatic encephalopathy (CHE) in patients with cirrhosis are lacking. In this study, we were able to demonstrate that sGFAP levels are associated with CHE in patients with cirrhosis. These results suggest that astrocyte injury may already occur in patients with cirrhosis and subclinical cognitive deficits and that sGFAP could be explored as a novel biomarker.

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关键词

Biomarkers,CHE,CHE, covert hepatic encephalopathy,Cognitive deficit,Complications of cirrhosis,GFAP,GFAP, glial fibrillary acidic protein,HE,HE, hepatic encephalopathy,HE2, grade 2 hepatic encephalopathy,MELD, model for end-stage liver disease,MHE, minimal hepatic encephalopathy,OHE, overt hepatic encephalopathy,OR, odds ratio,PHES, psychometric hepatic encephalopathy score,Psychometric hepatic encephalopathy score,ROC, receiver operating characteristic,SiMoA, single-molecule array,WBC, white blood cell,sGFAP, serum glial fibrillary acidic protein

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