In patients with hemophilia, a decreased thrombin generation profile is associated with a severe bleeding phenotype.

Marieke J A Verhagen,Waander L van Heerde,Johanna G van der Bom,Erik A M Beckers,Nicole M A Blijlevens,Michiel Coppens,Samantha C Gouw,Joop H Jansen,Frank W G Leebeek,Lize F D van Vulpen,Daniëlle Meijer,Saskia E M Schols

Research and practice in thrombosis and haemostasis（2023）

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摘要

A decreased thrombin generation profile is associated with a severe clinical bleeding phenotype in patients with hemophilia. Thrombin generation in combination with bleeding severity may be a better tool to personalize prophylactic replacement therapy irrespective of hemophilia severity.

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关键词

factor VIII,hemophilia A,hemophilia B,phenotype,thrombin

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