Differential CD4+ T-Cell Cytokine and Cytotoxic Responses Between Reactivation and Latent Phases of Herpes Zoster Infection.

Wenjie Jin,Mike Fang,Ismail Sayin,Carson Smith, Jeffrey L Hunter,Brian Richardson,Jackelyn B Golden,Christopher Haley,Kenneth E Schmader,Michael R Betts,Stephen K Tyring,Cheryl M Cameron,Mark J Cameron,David H Canaday

Pathogens & immunity（2022）

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摘要

In summary, VZV-specific CD4+ T cells from acute HZ individuals had unique functional and transcriptomic features, and VZV-specific CD4+ T cells as a group had a higher expression of cytotoxic molecules including Perforin, Granzyme-B, and CD107a.

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关键词

CD4 T cells,Herpes Zoster,T-cell polyfunction,VZV,transcriptomic

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